Expertise | Ultra Sensitive Ligand-Binding Assay Capabilities

Expertise |

Ultra sensitive immunoassays

 

ultra sensitive assay services

High sensitivity over a broad range

Bioanalytical assay development for sample testing services

Bioanalytical assay development for sample testing services beyond the limitations of classical immunoassays.

There is no need to invest in costly laboratory equipment and acquire internal expertise when using our ultra-sensitive platforms!
Continue working on your preferred in-house platform and only outsource case studies where improved sensitivities or an augmented performance criteria is a must.

Chimera is equipped and accustomed to developing ultra-sensitive assays from your specifications to fulfill your requirements. As pioneers for ultra-sensitive immunoassays with the longest track record in the CRO industry for ultra-sensitive bioanalytics, we specialize in case studies where standard ELISA quantification is just not powerful enough.

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Excellence in immunoassay development, validation and bioanalysis is our core motivation on all our platforms.

Excellence in immunoassay development and bioanalysis

Especially in the ultra-sensitive realm, construction, validation and reproducible manufacturing of standards (Ss) and corresponding quality control samples (QCs) for accurate quantification is key to fulfilling study needs and regulatory requirements.

Biomarkers and biotherapeutic drugs, however, have the potential to interact with the standard curve matrix in which the analyte is spiked into.

To avoid dilution effects when spiking the analyte
from stock storage buffer into the standardcurve matrix
and to avoid serial dilution effects, Chimera works with
dispenser technology down to the femto-liter (fl) volume range.

This allows direct spiking of a particular standard or QC concentration
into standardcurve matrix without the introduction of serial dilution effects.

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Ultrasensitiv Darstellung
Expertise

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Ultrasensitivity Pk ADA Assay support service

Ultra sensitivity

Our ultra-sensitive technologies at Chimera enable the precise measurement of even the lowest analyte concentrations. Trust our expertise for reliable and highly accurate bioanalytical results.

Microsampling Pk ADA Assay service

Microsampling

Our microsampling technology at Chimera Biotec enables precise analyses even with minimal sample volumes. This gives you reliable results, even when only the smallest amounts of biological material are available.

AnySource PK ADA Assay service

AnySource®

With AnySource® from Chimera Biotec, we offer flexible sample solutions that ensure the highest accuracy and reliability. No matter what sample material you use, our technology adapts to your requirements and delivers precise bioanalytical results.

GLP PK ADA Assay service support

GLP/GCP quality

Our services at Chimera comply with strict GLP/GCP quality standards to guarantee you the highest reliability and reproducibility. Trust our expertise for precise and compliant bioanalytical results.

plexing pk Ada Assay service support

Polyplexing

Our polyplexing technology at Chimera enables the simultaneous detection of multiple analytes in a single sample. This significantly increases the efficiency and informative value of your studies by providing comprehensive and precise bioanalytical results.

MSD immuno Assay development 96 Well
GLP GCP service support immunoassay

GLP/GCP quality

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Chimera Biotec: Ultra-sensitive bioanalysis & beyond

Large-molecule sample testing support from the industry’s longest standing experts for ultra-sensitive bioanalysis

 

Why ultra sensitivity:

While the sensitivities of a classic, colorimetric ELISA (enzyme linked immunosorbent assay) are sufficient for bioanalysis in many cases, there is a growing interest in immunoassay techniques whose detection capabilities go beyond those of ELISA. The complexity and novel mechanisms of action of contemporary, biotherapeutic drugs (biologics) increasingly demand ultra-sensitive detection methods for both PK sample testing as well as for endogenous or drug-related, low abundance biomarkers.

Who we are:

Your GLP/GCP lab in Europe. As pioneers in the field, chimera biotec has been specialized in supporting drug development programs that demand the highest bioanalytical quality since 2000. Our long-standing expertise in beyond-ELISA-sensitivity immunoassays enables us to make the most out of any immunoassay platform and provide our customers with accurate and comprehensive scientific results.

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What we do:

For more than 20 years, Chimerahas specialized on supporting drug development programs with the highest demands on bioanalytical quality. We develop and validate ultra-sensitive immunoassays in accordance with the regulatory requirements, industry best practice, whitepapers, and bioanalytical method validation guidance documents.

Based on your experience on your preferred in-house immunoassay platform, we can run a technology evaluation and feasibility study across our ultra-sensitive platforms. The resulting data will allow you to select the platform best suited to support your study’s bioanalytical needs.

 

What makes us different:

With our expert knowledge in sample dilution – based on our proprietary AnySource® technology – we can utilize our sensitivity to tailor your assay towards alternate needs, such as minimal sample consumption for bioanalytical studies involving microsampling or rare matrices.

 

Our quality standards:

Our GLP/GCP certified laboratories deliver bioanalytical services ranging from non-regulated research processing of a few samples to the handling of thousands of samples for clinical phase-III research on time.

Chimera Biotec – your partner for excellent biomedical research.

Locations of the laboratories

Location advantages

Bremen

Our laboratory location in Bremen offers ideal logistical conditions for efficient sample delivery. Thanks to the excellent transport connections, your samples will reach us quickly and reliably. We use our strategically located site to map our fast and smooth logistics processes.

Dortmund

Our laboratory location in Dortmund benefits from the dynamic innovative power of the city, which is known as an important center for technology and research. Together with our laboratory in Bremen, we offer you a high level of redundancy and additional security for your projects thanks to two locations. Take advantage of our first-class infrastructure and secure reliable and continuous support for your biotechnological requirements!

 

Chimera Dortmund Chimera Bremen

Precision and care in handling biological specimens

At Chimera, our experienced and continuously trained staff ensures that even the smallest sample volumes are analyzed with the highest accuracy

In addition, how your biological specimens are handled is of great importance – particularly in rare matrix or microsampling study support – wherever limitations on sample volume availability apply.

Here at Chimera,we treat your sample extremely carefully. Since even state of the art laboratory equipment can only be as good as the person operating it, our experienced laboratory staff receives ongoing training.
As an example, our technicians individually calibrate their own pipettes to ensure accurate pipetting of sample volumes as low as 0.5 µl (500 nl). Experienced and properly trained personnel, together with constant quality monitoring and improvement are vital for ultra-sensitive bioanalytical GLP/GCP services.

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Expertise | Ultra Sensitive Ligand-Binding Assay Capabilities

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