The Immunogenicity Gold Standard

MESO SCALE DISCOVERY™

MSD-ECL from Meso Scale Discovery is a proven electrochemiluminescence immunoassay platform for large molecule analysis. The ECL technology enables high sensitivity levels combined with broad assay range, making MSD™ ideal for immunogenicity testing, multiplex biomarker screening and cytokine assays.

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20 years of in-depth experience

Imperacer®

The award-winning Immuno-PCR (IPCR) based ligand-binding assay platform. Chimera’s proprietary ultra sensitive immunoassay technology that combines the exquisite of ELISA-based antibody specificity with the most sensitive detection system in molecular biology: real-time qPCR.

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Technologies MSD | MESO SCALE DISCOVERY by MESO SCALE DIAGNOSTICS for immunoassays

MSD™ – Meso Scale Discovery

The Immunogenicity Gold Standard

MSD-ECL from Meso Scale Discovery is a proven immunoassay platform for large molecule analysis. The ECL technology enables high sensitivity levels combined with broad assay range, making MSD™ ideal for immunogenicity testing, multiplex biomarker screening and cytokine assays.

We offer MSD™ immunoassays under GLP, GCP and non-regulated.

Chimera Biotec offers full Immuno-PCR testing service for all your bioanalytical needs. Check out our Biomarker Menu for available validated assays. We also develop an ultra-sensitive Imperacer® assay based on your specific requirements.

MSD™ | MESO SCALE DISCOVERY a MESO SCALE DIAGNOSTICS technology

In ECL immunoassays, the intensity of light signals emitted due to electricity applied to the plate electrodes is measured. Tripropylamine-containing buffers catalyze a dual redox reaction with Ruthenium emitting light at 620 nm. The MSD-ECL platform uses SULFO-TAG labeled antibodies – and since only labels near the electrode surface are detected – ensures low background noise.

Compared to traditional ELISA methods, the amplified MSD electrochemiluminescence labels yield higher sensitivity, a broad dynamic range and multiplex arrays allow the detection of several analytes from a single sample (e.g. whole blood, serum, plasma, supernatant).Low background and low interference also enable the quantification of analytes in complex matrices.

Read our case studies and publications to learn more about MSD™.

MSD MESO SCALE DIAGNOSTICS assay technology services csm

Msd MESO SCALE DIAGNOSTICS immuno assay service sample testing 120 system

Application Services

Biomarker

Our high-precision biomarker assays offer you reliable and fast results that make a decisive contribution to optimizing your research and clinical studies. Rely on our expertise and state-of-the-art technology to take your projects to the next level.

PK/PD Pharmacokinetics

Our PK/PD pharmacokinetic assays provide you with precise and meaningful data that is essential for the successful development and approval of new therapies. Take advantage of our advanced technology and expertise to drive your drug development forward.

ADA/Immunogenicity

Our ADA/immunogenicity assays provide you with reliable and sensitive analyses that are crucial for evaluating the safety and efficacy of your biological therapies. Rely on our expertise and state-of-the-art methodology to comprehensively assess the immunogenicity risk of your products.

Literatur ADA and NAb Immunogenicity PK bioanalytical Pharmacokinetic Assays

Literature

Our comprehensive literature search and evaluation provides you with sound and up-to-date scientific findings to support your research and decision-making processes.

Imperacer

MSD

ELISA

Simoa

Enhanced sensitivity with TURBO-TAG: Optimized MSD™ procedure featuring innovative TURBO-BOOST and S-PLEX reagents

Modifying the standard MSD™ procedure, the TURBO-TAG label allows us to provide MSD service of improved sensitivity.

The detection antibody is labeled with TURBO-BOOST which is enhanced in an additional step and then bound by an electrochemiluminescence TURBO-TAG molecule. Additional S-PLEX reagents reduce non-specific signals.

Using the MSD GOLD Read Buffer, the applied voltage causes the captured TURBO-TAG labels to emit light.

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Locations of the laboratories

Location advantages

Bremen

Our laboratory location in Bremen offers ideal logistical conditions for efficient sample delivery. Thanks to the excellent transport connections, your samples will reach us quickly and reliably. We use our strategically located site to map our fast and smooth logistics processes.

Dortmund

Our laboratory location in Dortmund benefits from the dynamic innovative power of the city, which is known as an important center for technology and research. Together with our laboratory in Bremen, we offer you a high level of redundancy and additional security for your projects thanks to two locations. Take advantage of our first-class infrastructure and secure reliable and continuous support for your biotechnological requirements!

Chimera Dortmund Chimera Bremen

V-Plex Technology

V-Plex: Precise validation and comprehensive certificates of analysis for maximum reliability

The “V” stands for validated, since V-Plex plates undergo an accurate validation and are shipped with a certificate of analysis (CofA).
The validation includes:

Percent recovery of each analyte and % CV
LLOQ and ULOQ
Percentage of nonspecific binding
Standard curve data for each analyte with % CV for each concentration

MSD™ V-Plex plates offer exceptional reliability through rigorous validation. Each plate comes with a detailed Certificate of Analysis (CofA) that provides comprehensive information on analyte performance.

The validation of each V-Plex plate includes the production of at least three kit lots, performed with independent raw material batches when available. These are tested in multiple runs, on multiple days, and by multiple analysts. This thorough validation ensures that V-Plex plates deliver consistent and reliable results, essential for demanding research applications.

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CENiBRA: Chimera Biotec’s Sales Partner

CENiBRA life science solutions is chimera biotecs sales and distribution partner.

Chimera’s MSD™ expertise

In addition to our ultra-sensitive sample testing, MSD™ offers a comprehensive suite of bioanalytical solutions designed to meet the highest standards of precision and reliability. Our advanced technologies, including the proprietary TURBO-TAG and S-PLEX reagents, ensure enhanced sensitivity and specificity in your assays. With a commitment to innovation and quality, MSD™ supports your research with validated platforms and detailed Certificates of Analysis, providing you with the confidence and accuracy needed for groundbreaking discoveries.

Platform intrinsic advantages

Highly sensitive assays
Fast and automated platform
Wide range of assay kits

Our services at a glance

In-house antibody pair testing
Assay development services
Multiplex biomarker assays
PK assays
Assay transfer
Assay validation (fit-for-purpose, non-reg., GLP confirm validation)
Regulated bioanalysis (non-reg / GCP / GLP)

Take advantage of Chimera‘s more than 20 years of in-depth experience as a specialty CRO for immunoassays which go beyond the scope of what is usually considered feasible.

Benefit from the best in class in immunoassay sensitivity!

Contact us

Discover the benefits of our first-class solutions! Press the contact button now to arrange a free meeting with one of our scientists. Take advantage of this unique opportunity to clarify your questions and receive individual advice for your projects. Let our expertise convince you and take your research to the next level!

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MSD™ immunoassay services:

Our kit-based biomarker portfolio for MSD™. If you can not find your biomarker of interest, we develop a highly specific custom assay for you. Just contact our team of experts.

Preconfigured multiplex biomarker portfolio for MSD™